For a big variety of assays during the Drug Discovery process from High Throughput Screening to Lead Optimization assays, huge amounts of assay ready plates need to be generated by dispensing small volumes of compounds and precise amounts of buffers. Due to the amounts of plates generated, automation is essential.
Different liquid handling techniques can be used for this. For dispensing of nanoliter amounts of compounds and dispensing of bulk reagents, acoustic dispensers and bulk dispensers can be integrated. Copying or combination of plates can be done with the 96 or 384 pipetting head. Dilution series for different concentrations of compound enabling dose response studies can be generated by using regular pipetting channels or by using one or multiple columns of the pipetting heads. Due to the variable span pipetting channels, hits generated in a previous screen can be easily cherry picked.